Transcription Factor HES-1: How Is the Expression of This Transcriptional Factor in Paucibacillary Leprosy Patients?

INTRODUCTION: Leprosy is an ancient and chronic infectious disease caused by 2 mycobacteria (Mycobacterium leprae and Mycobacterium lepromatosis). Recently, our research group observed that HES-1, an innate cellular component of the Notch signaling pathway, is related to the pathogenesis of leprosy. Therefore, it could be helpful in its detection. OBJECTIVE: To determine the expression of HES-1 in the skin of patients with paucibacillary (PB) leprosy. METHODS: A cross-sectional, descriptive, observational study was conducted. Forty-five skin samples from patients with leprosy were evaluated (30 samples from MB leprosy and 15 from PB leprosy) using immunohistochemistry of HES-1 and S-100. RESULTS: PB leprosy biopsies revealed a reduction of HES-1 in 66.7% of the epidermis, 80% of the eccrine glands, and 62.5% of the hair follicles of these patients, with statistical differences in the control group (P < 0.0001). Besides, HES-1 showed similar utility to S-100 immunostaining in detecting the MB and PB leprosy. CONCLUSIONS: HES-1 is a transcriptional factor also reduced in PB patients' epidermis and skin appendages. Finally, our data show that HES-1 could be a biomarker in diagnosing PB and MB leprosy.

Intervención de enfermería para la disminución de la ansiedad ante el parto vaginal / Efficacy of nursing intervention management of anxiety before vaginal delivery

El parto vaginal, se conoce como el comienzo espontáneo, o ciclo natural, que permite llegar al final exitoso de la gestación en la mujer. Objetivo: determinar la eficacia de la intervención de enfermería manejo de la ansiedad en mujeres gestantes frente al parto, en el Hospital de segundo nivel en San Gil, Santander. Materiales y métodos: es un estudio cuasi-experimental, con un solo grupo la muestra estuvo conformada 29 mujeres gestantes que cumplieran con los criterios de inclusión, la información se obtuvo a través del cuestionario de ansiedad estado rasgo STAI "State-Trait Anxiety Inventory (Self Evaluation Questionnaire)". Resultados: Se encontró que el promedio de la edad de las gestantes que participaron en el estudio fue de 24 años, el estado civil de más de la mitad de las gestantes es unión libre con un 65,5%. La diferencia de medias entre las puntuaciones pre y post obtuvieron una significación estadística. La media de las puntuaciones de la variable ansiedad estado disminuyo antes (x = 22,3) después de la intervención (x = 20). Conclusión: Se logró describir el nivel la ansiedad en las gestantes y al realizar la comparación de la prueba pre y post se evidenció una disminución en el nivel de ansiedad, por tanto, se debe trabajar en un plan de cuidados, tal como en la teoría de cuidados de Swanson, debe ser un trabajo humanístico hacia las personas a nuestro cuidado. (AU)

Vaginal birth is known as the spontaneous onset, or natural cycle, which allows the successful end of pregnancy in women. Objective: to determine the effectiveness of the nursing intervention anxiety management in pregnant women against childbirth, in the second level Hospital in San Gil, Santander. Materials and methods: is a quasi-experimental study, with a single group the sample consisted of 29 pregnant women who met the inclusion criteria, the information was obtained through the STAI state anxiety trait questionnaire "State-Trait Anxiety Inventory (Self Evaluation Questionnaire)" Results: It was found that the average age of the pregnant women who participated in the study was 24 years, the marital status of more than half of the pregnant women is free union with 65.5%. The difference in means between the pre and post scores obtained a statistical significance. The mean scores of the state anxiety variable decreased before (x = 22.3) after the intervention (x = 20). Conclusions: It was possible to describe the level of anxiety in pregnant women and when comparing the pre and post test, a decrease in the level of anxiety was evidenced, therefore it is necessary to work in a care plan, such as in the theory of care from Swanson, it must be a humanistic work towards the people in our care. (AU)